The frequency study of anti HLA antibodies of platelet in patients who received blood component in Imam Reza and Taleghani hospitals in Kermanshah

AUTHORS

Daryoush Pourmand 1 , Soraya Bilvaye 1 , * , Bahram Ebrahimi 2 , Mozafar Aznab 3 , Sahar Afzali 1 , Shahin Karimi 4 , Seyed Siamak Peyambari 3

1 Department of Medical Laboratory Sciences, Paramedicine Faculty, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Blood Transfusion Organization Kermanshah, Kermanshah, Iran

3 Department of Oncology, Taleghani Hospital, Kermanshah, Iran

4 Department of Oncology, Imam Reza Hospital, Kermanshah, Iran

How to Cite: Pourmand D , Bilvaye S , Ebrahimi B , Aznab M, Afzali S, et al. The frequency study of anti HLA antibodies of platelet in patients who received blood component in Imam Reza and Taleghani hospitals in Kermanshah, J Clin Res Paramed Sci. 2015 ; 4(1):e81959.

ARTICLE INFORMATION

Journal of Clinical Research in Paramedical Sciences: 4 (1); e81959
Published Online: May 17, 2015
Article Type: Brief Report
Received: November 12, 2014
Accepted: March 25, 2015

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Abstract

There are alloantibody in the patient with hematologic disorders like acute leukemia and multiple blood transfusion. These alloantibodies are IgM and IgG antibodies against
alloantigens of platelets like HLA antigen.


Platelets resistant was detected in 2-30% of patients with blood transfusion and in 50% patients case a unsuitable respond to platelet transfusion in patients.


In this descriptive analytic Study anti platlet antibodes were detected by lymphocytotoxicity method in 18 patients that received blood and blood components in Imam Reza and Taleghani hospitals.


Anti HLA antibodies detected in 9 of 18 sample of patients with blood disorder and malignance. The mean of old in samples was 24.5 years.


Anti HLA antibodies were detected in 50% of study patients. There were not significant related in anti HLA antibodies and FFP, platelet rates and times of hospitalization. But between ratty and times of pack cell transfusion and anti HLA antibodies a significant related was seen.
 

Keywords

Alloantibody Platelet Alloantigen lymphocytotoxicity test

© 2015, Journal of Clinical Research in Paramedical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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