Multidrug resistance in Pseudomonas aeruginosa and Enterobacter cloacae isolated from intensive care units of Qazvin and Tehran hospitals

AUTHORS

Amir Peymani 1 , Moein‏ ‏Yeylagh Beigi 2 , Mahdi‏ ‏‎ ‏ Mohammadi Ghanbarlou‎ 2 , Reza Najafipour 1 , Rasoul‏ ‏Samimi ‎ 3 , *

1 Cellular and Molecular‏ ‏Research Center, Qazvin‏ ‏University of Medical‏ ‏Sciences, Qazvin‎, Iran

2 Department of Medical‏ ‏Microbiology, Qazvin‏ ‏University of Medical‏ ‏Sciences, Qazvin‎, Iran

3 Department of Internal‏ ‏Medicine, School of Medicine,‎‏ ‏Qazvin University of Medical‏ ‏Sciences, Qazvin‎, Iran

How to Cite: Peymani A , ‏Yeylagh Beigi M, Mohammadi Ghanbarlou‎ M ‏ ‏, Najafipour R , ‏Samimi ‎ R. Multidrug resistance in Pseudomonas aeruginosa and Enterobacter cloacae isolated from intensive care units of Qazvin and Tehran hospitals, J Clin Res Paramed Sci. 2014 ; 3(1):e82084.

ARTICLE INFORMATION

Journal of Clinical Research in Paramedical Sciences: 3 (1); e82084
Published Online: May 14, 2014
Article Type: Research Article
Received: October 10, 2013
Accepted: March 19, 2014

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Abstract

Introduction: Pseudomonas aeruginosa and Enterobacter cloacae are the most common organisms involved in clinical disease among patients admitted in ICUs. The treatment of these infections is often difficult due to several virulence factors and drug resistance
mechanisms. The aim of this study was to evaluate multidrugresistance pattern among clinical P. aeruginosa and E. cloacae isolates collected from ICUs.
Methods: In total, 82 and 49 P. aeruginosa and E. cloacae isolates were collected from ICUs of Tehran and Qazvin hospitals. The species identification was performed by standard laboratory methods. Antimicrobial susceptibility and multidrug resistance (MDR) pattern
were further evaluated by Kirby-Baure method according to CLSI guideline.
Results: In this study, the highest resistance rate was shown to cefpodoxime (98.8%) and cefotaxime (97.6%) in P. aeruginosa and to amoxicillin-clavulanic (98%) acid and ampicillin (95.9%) in E. cloacae isolates. Twenty six (53.1%) E. cloacae and 43 (52.4%) P. aeruginosa isolates showed the multidrug resistance pattern.
Conclusion: The present study showed the considerable frequency of MDR pattern among P. aeruginosa and E. cloacae isolates collected from studied hospitals. Therefore, there is need for efficient infection control and appropriate therapeutic practices, especially in ICUs.
 

Keywords

Enterobacter cloacae Pseudomonas aeruginosa MDR IC

© 2014, Journal of Clinical Research in Paramedical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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