The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells

AUTHORS

Samira Rasaneh 1 , * , Saleh Salehi Zahabi 2

1 Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran

2 Department of Radiology and Nuclear Medicine, Paramedicine School, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Rasaneh S, Salehi Zahabi S . The effect of chitosan nanoparticles containing paclitaxel on destruction of breast cancer cells, J Clin Res Paramed Sci. 2016 ; 4(4):e82069.

ARTICLE INFORMATION

Journal of Clinical Research in Paramedical Sciences: 4 (4); e82069
Published Online: January 05, 2016
Article Type: Research Article
Received: June 04, 2015
Accepted: November 06, 2015

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Abstract

Background: Paclitaxel is a new chemotherapy medicine that is used for treating breast, ovarian, and lung cancers as well as AIDS-related Kaposi's sarcoma. Due to the side effects of using this drug, the paclitaxel-loaded chitosan nanoparticles was synthesized and its cytotoxicity effects on breast cancer cell lines was examined.

Methods: The paclitaxel-loaded chitosan nanoparticles were synthesized by the gelation method, purified and isolated in a proper size by centrifugation. The nanoparticles’ size, percentage of loading and releasing time of the drug up to 24 hours and its cytotoxicity effects, compared with Paclitaxel; on breast cancer cell lines were investigated.

Results: Particle sizes revealed to be 248-312 nm using the zetasizer system, the drug loading percentage showed 55±4 %, and the rate of drug releasing time for 24 h measured 5.5 %. On the average in concentration of 0.8 μg/mL the cytotoxicity of the paclitaxol-loaded chitosan nanoparticles was estimated 43% less than that of the taxol.

Conclusion: The results showed that the paclitaxol-loaded chitosan nanoparticles may be considered as a good alternative to taxol since it decreases the related side effects. However, it deserves further investigations in future.

Keywords

Paclitaxol Chitosan nanoparticles Drug delivery Breast cancer

© 2016, Journal of Clinical Research in Paramedical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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