Evaluation of single dose Pregabalin vs. placebo in reducing post– Photorefractive Keratectomy pain

AUTHORS

Mansour Chubsaz 1 , Farid Daneshgar 2 , Nasrin Amiri Fard‎ 3 , * , Tayebeh Kazerooni‎ 1 , Ebrahim Ghaderi‎ 4

1 Department of Anesthesiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

2 Department of Ophthalmology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

3 Department of Radiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

4 Eye Research Center, Kermanshah University of Medical Sciences, Kermanshah‎, Iran

How to Cite: Chubsaz M , Daneshgar F, Amiri Fard‎ N , Kazerooni‎ T , Ghaderi‎ E . Evaluation of single dose Pregabalin vs. placebo in reducing post– Photorefractive Keratectomy pain, J Clin Res Paramed Sci. 2014 ; 3(3):e82116.

ARTICLE INFORMATION

Journal of Clinical Research in Paramedical Sciences: 3 (3); e82116
Published Online: October 13, 2014
Article Type: Research Article
Received: March 09, 2014
Accepted: August 14, 2014

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Abstract

Background: Today, Photorefractive keratectomy (PRK) is one of the most common methods of eye surgery and the most important problem of patient and medical team that are confronted about this surgery is pain. The aim of this study was to determine the
efficacy of Pregabalin for reducing post–photorefractive keratectomy (PRK) pain.
Methods: This study was done as a double blind clinical trial. Patients were divided in two groups (40 patients in each group) as case and control and 30 minute before surgery 150 mg Pregabalin and placebo were prescribed for case and control groups, respectively. In 6, 12 and 24 hours after surgery, pain was measured by Visual Analog Scale (VAS).
Results: The results of this study were showed pain score in 6 and 12 hours after surgery in Pregabalin group was significant lower than control (P<0.001). In Pregabalin group, after 6 hours, 17 patients (42.5%) had VAS score >3 and needs to Acetaminophen;
whereas in control group 33 patients (82.5%) had VAS score >3 (P<0.001). Further, there wasn't any side effect in Pregabalin group.
Conclusion: Our study showed Pregabalin is an effective and with low side effect medicine for reducing of post–photorefractive keratectomy pain.

 

Keywords

Photorefractive keratectomy Pregabalin pain Visual Analog Scale

© 2014, Journal of Clinical Research in Paramedical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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