Effects of Curcumin on Reproductive Parameters in Male Mice

AUTHORS

Mohammad Reza Salahshoor 1 , Cyrus Jalili 1 , * , Mozafar Khazaei 1 , Fuzie Khani 2

1 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Anatomy, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Salahshoor M R, Jalili C , Khazaei M , Khani F . Effects of Curcumin on Reproductive Parameters in Male Mice, J Clin Res Paramed Sci. 2012 ; 1(3):e82189.

ARTICLE INFORMATION

Journal of Clinical Research in Paramedical Sciences: 1 (3); e82189
Published Online: October 09, 2012
Article Type: Research Article
Received: March 15, 2012
Accepted: August 20, 2012

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Abstract

Backgrand: Infertility is a health problem that causes adverse effects in personal, social and
economic domains. Infertility in males has been associated with sperm dysfunctions such as low
sperm count, immaturity, abnormality and lack of motilty. The color of turmeric is because of a
substance called curcumin for which some anti-oxidative and anti-inflammatory properties have been
identified. Although researchers have reported the anti-oxidant properties of curcumin, its effects on
reproductive hormones, epididymis pathway, and sperm count and motility in nicotine-infected rats
have not been investigated.
Methodes In this study, various doses of curcumin (10, 30 and 60 mg/kg) were administered intraperitoneally to male mice for 28 consequent days and reproductive parameters as testosterone
hormone, motility, morphology, testis weight and histology were analyzed and compared.
Results: The results indicated that increasing the dose of curcumin significantly increased
reproductive indices such as sperm count, motility, testis weight and testosterone hormone in most
of the groups (P≤05).
Conclusions: It seems that curcumin increase the quality and quantity of reproductive indices in
male mice.

Keywords

Curcumin reproductive parameters Male mice

© 2012, Journal of Clinical Research in Paramedical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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