Frequency ofantibodies againstbloodgroup antigens in patient ofGhaem hospitalMashhad

AUTHORS

Mohammad Hadi Sadeghian 1 , Seyede Fateme Shams 2 , * , Toktam Saneie 2 , Seyed Masoud Alavi 3 , Ahmad Ashjaee 3 , Mohsen Dashti 3

1 Department of hematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad‎, Iran

2 Department of Medical Laboratory Sciences, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Blood Bank, Mashhad University of Medical Sciences, Mashhad, Iran

How to Cite: Sadeghian M H , Shams S F , Saneie T , Alavi S M , Ashjaee A , et al. Frequency ofantibodies againstbloodgroup antigens in patient ofGhaem hospitalMashhad, J Clin Res Paramed Sci. 2013 ; 1(4):e82294.

ARTICLE INFORMATION

Journal of Clinical Research in Paramedical Sciences: 1 (4); e82294
Published Online: January 17, 2013
Article Type: Research Article
Received: June 06, 2012
Accepted: November 12, 2012

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Abstract

Introduction: Most blood group alloantibodies are generated by mismatched transfusion as
the result of foreign erythrocyte antigen exposure to the immune system. This study was done
to determine the frequency of blood group alloantibodies in patients who admitted in Ghaem
hospital of Mashhad-Iran.
Method: This cross sectional study was done on 525 patientsin Ghaem Hospital of Mashhad
University of Medical Sciences. The ABO and Rh Blood groups were typed by two methods
of cell type and back type. Red blood cell alloantibodies were detected in patients' serum by
screen antibody kit. All data recorded in computer and analyzed by SPSS version13.
Result: 296 of 525 patients were male and 229 of them were female. Red cell antibodies
were detected in 48 patients consisting one autoantibody and 47 alloantibodies. Warm
allantibodies found in 11 patients and cold alloantibodies detected in 36 patients.
Conclusion: Higher frequency of all immunization was observed in female in compare to
male. This study demonstrates the relationship between the type of blood group and existence
of cold alloantibody. The higher frequency of cold alloantibodies was in people with B blood
group type.

Keywords

alloantibody auto antibody antibody screening

© 2013, Journal of Clinical Research in Paramedical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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